List of companies headquartered in San Francisco

Tourism is the backbone of the San Francisco economy. Its frequent portrayal in music, film, and popular culture has made the city and its landmarks recognizable worldwide. It is the city where Tony Bennett "left his heart," where the Birdman of Alcatraz spent many of his final years, and where Rice-a-Roni[110] was said to be the favorite treat. San Francisco attracts the third-highest number of foreign tourists of any city in the U.S.[dated info][19] and claims Pier 39 near Fisherman's Wharf as the third-most popular tourist attraction in the nation.[111] More than 16 million visitors arrived in San Francisco in 2007, injecting nearly $8.2 billion into the economy—both all-time high figures for the city.[112] With a large hotel infrastructure and a world-class convention facility in the Moscone Center, San Francisco is also among the top-ten North American destinations for conventions and conferences.[113]

The legacy of the California Gold Rush turned San Francisco into the principal banking and finance center of the West Coast in the early twentieth century. Montgomery Street in the Financial District became known as the "Wall Street of the West," home to the Federal Reserve Bank of San Francisco, the Wells Fargo corporate headquarters, and the site of the now-defunct Pacific Coast Stock Exchange. Bank of America, a pioneer in making banking services accessible to the middle class, was founded in San Francisco and in the 1960s, built the landmark modern skyscraper at 555 California Street for its corporate headquarters. Many large financial institutions, multinational banks and venture capital firms are based in or have regional headquarters in the city. With over 30 international financial institutions,[20] seven Fortune 500 companies,[114] and a large support infrastructure of professional services—including law, public relations, architecture and design—also with significant presence in the city, San Francisco is designated as one of the ten Beta World Cities.[115] The city ranks eighteenth in the world's list of cities by GDP, ninth in the United States, and is fifteenth place in the top twenty Global Financial Centres Index.[116][117]
The San Francisco Financial District skyline framed by the Transamerica Pyramid and the Bank of America building.

San Francisco's economy has increasingly become tied to that of its Bay Area neighbor San Jose and Silicon Valley to its south, sharing the need for highly educated workers with specialized skills.[118] Due to such links with Silicon Valley, San Francisco became an epicenter of the Dot-Com bubble of the 1990s-2000s, and the subsequent Web 2.0 boom of the late 2000s. Many popular and prominent Dot-Com companies and "start-ups" such as Craigslist.org, Twitter, Salesforce.com, and the Wikimedia Foundation among others have established their head offices in San Francisco.

San Francisco has been positioning itself as a biotechnology and biomedical hub and research center. The Mission Bay neighborhood, site of a second campus of UCSF, fosters a budding industry and serves as headquarters of the California Institute for Regenerative Medicine, the public agency funding stem cell research programs statewide. As of 2009, there were 1,800 full-time biochemists and biophysicists employed in San Francisco, with an annual mean wage of $92,620

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